Vanessa Desantis, Antonio G Solimando, Domenico Ribatti
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引用次数: 0
摘要
表观遗传学研究的是那些在不改变 DNA 序列的情况下调节基因表达并通过细胞分裂遗传的改变。DNA的低甲基化、肿瘤抑制基因的高甲基化、组蛋白的异常修饰和/或特定微RNAs的表达谱都有助于肿瘤的发生和发展。在本综述中，我们将讨论表观遗传变化在调控肿瘤血管生成中的作用。
Epigenetic regulation of angiogenesis in tumor progression.
Epigenetic is the study of those alterations regulating gene expression without altering DNA sequence and inherited by transmission through cell division. DNA hypomethylation, hypermethylation of tumor suppressor genes, aberrant histone modifications and/or specific microRNAs expression profiles contribute to tumor initiation and progression. In this review, we will discuss the role of epigenetic changes in the regulation of tumor angiogenesis.
期刊介绍：
Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.
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