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引用次数: 0
摘要
人体内的神经免疫交流是人体两个中枢调节系统(即神经系统和免疫系统)之间的桥梁。胆碱能系统是中枢和外周神经系统中一种重要的调节神经递质。它包括神经递质乙酰胆碱(ACh)、合成 ACh 所需的酶(胆碱乙酰转移酶,ChAT)、降解 ACh 所需的酶(乙酰胆碱酯酶,AChE)以及胆碱能受体(烟碱乙酰胆碱受体和毒蕈碱乙酰胆碱受体)。神经元中的胆碱能系统在认知功能、感官知觉、运动控制、学习和记忆过程中的作用众所周知。研究表明,非神经元胆碱能系统(NNCS)存在于各种组织和免疫细胞中,并形成神经免疫通讯系统。在本综述中,我们讨论了免疫细胞上的非神经元胆碱能系统、它在肠道平衡和炎症反应中的作用,以及如何利用它来治疗炎症反应。
Neuroimmune communication of the cholinergic system in gut inflammation and autoimmunity
Neuroimmune communication in the body forms a bridge between two central regulatory systems of the body, i.e., nervous and immune systems. The cholinergic system is a crucial modulatory neurotransmitter in the central and peripheral nervous system. It includes the neurotransmitter acetylcholine (ACh), the enzyme required for the synthesis of ACh (choline acetyltransferase, ChAT), the enzyme required for its degradation (acetylcholinesterase, AChE), and cholinergic receptors (Nicotinic acetylcholine receptors and muscarinic acetylcholine receptors). The cholinergic system in neurons is well known for its role in cognitive function, sensory perception, motor control, learning, and memory processes. It has been shown that the non-neuronal cholinergic system (NNCS) is present in various tissues and immune cells and forms a neuroimmune communications system. In the present review, we discussed the NNCS on immune cells, its role in homeostasis and inflammatory reactions in the gut, and how it can be exploited in treating inflammatory responses.
期刊介绍:
Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers.
The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences.
In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations.
Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.