丝氨酸蛋白酶重塑细胞外基质是癌症发生和发展的先决条件。

IF 4.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Matrix Biology Pub Date : 2024-11-03 DOI:10.1016/j.matbio.2024.10.007
Tomasz Wenta , Paulina Nastaly , Barbara Lipinska , Aki Manninen
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引用次数: 0

摘要

细胞外基质(ECM)是组织的物理支架,由结构蛋白(如层粘连蛋白、胶原蛋白、蛋白多糖和纤连蛋白)和其他多种具有 ECM 重塑和信号功能的基质蛋白组成,形成一个三维网络。ECM 相关信号蛋白的活性受到严格调控。因此,ECM 是水分和生长调节信号的储存库。ECM 结构由多种丝氨酸蛋白酶动态调节,这些蛋白酶可处理结构蛋白和信号蛋白,从而调节器官生成和组织稳态等生理过程,但它们也会导致病理事件,尤其是癌症进展。在此,我们回顾了目前有关丝氨酸蛋白酶(KLKs、uPA、呋喃、HtrAs、颗粒酶、matriptase、hepsin)重塑 ECM 在肿瘤发生中的作用的文献。
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Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression
The extracellular matrix (ECM) serves as a physical scaffold for tissues that is composed of structural proteins such as laminins, collagens, proteoglycans and fibronectin, forming a three dimensional network, and a wide variety of other matrix proteins with ECM-remodeling and signaling functions. The activity of ECM-associated signaling proteins is tightly regulated. Thus, the ECM serves as a reservoir for water and growth regulatory signals. The ECM architecture is dynamically modulated by multiple serine proteases that process both structural and signaling proteins to regulate physiological processes such as organogenesis and tissue homeostasis but they also contribute to pathological events, especially cancer progression. Here, we review the current literature regarding the role of ECM remodeling by serine proteases (KLKs, uPA, furin, HtrAs, granzymes, matriptase, hepsin) in tumorigenesis.
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来源期刊
Matrix Biology
Matrix Biology 生物-生化与分子生物学
CiteScore
11.40
自引率
4.30%
发文量
77
审稿时长
45 days
期刊介绍: Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.
期刊最新文献
Corrigendum to "Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer" [Matrix Biol. 81 (2019) 17-33]. Editorial Board Identification of CD44 as a key engager to hyaluronic acid-rich extracellular matrices for cell traction force generation and tumor invasion in 3D Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair
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