嗜酸性粒细胞胃肠道疾病:关于亚洲临床观点和研究差距的叙述性综述。

IF 3.8 Q2 GASTROENTEROLOGY & HEPATOLOGY Translational gastroenterology and hepatology Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI:10.21037/tgh-24-34
Fang Kuan Chiou, Lay Queen Ng, Wenyin Loh
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引用次数: 0

摘要

背景和目的:嗜酸性粒细胞胃肠病(EGID)是一组异质性疾病,包括嗜酸性粒细胞食管炎(EoE)和非 EoE EGID,已引起了相当大的研究兴趣。不同饮食、环境和文化背景的人群在疾病特征上可能存在差异。然而,我们对 EGID 的了解大多来自欧洲和北美的研究。本综述旨在总结 EGID 的最新进展和更新,重点关注亚洲患者的疾病表型,并确定未来有关亚洲人群疾病谱的研究机会:在 PubMed 上系统检索了截至 2024 年 3 月的原创研究、系统综述、荟萃分析和综述文章,重点关注过去 10 年中发表的新研究。排除了病例报告、会议摘要和非英文发表的文章:据报道,随着时间的推移,咽鼓管哮喘和非咽鼓管哮喘的患病率和发病率在全球范围内均有所上升,但在亚洲却缺乏基于人群的研究。根据来自亚洲数量有限的研究的异质性数据,与西方患者相比,亚洲的咽鼓管哮喘和非咽鼓管哮喘患者在流行病学、临床表型和治疗反应方面可能存在明显差异。此外,新型生物疗法(如杜比单抗)在亚洲人群中的疗效尚未得到明确界定:结论:亚洲缺乏有关 EGID 许多基本方面的可靠数据。我们迫切需要在亚洲更广泛的地区建立研究网络和合作关系,采用标准化和统一的标准收集高质量的多中心数据,更准确地了解亚洲患者的EGID情况,从而弥补这一差距。
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Eosinophilic gastrointestinal disorders: a narrative review on clinical perspectives and research gaps in the Asian context.

Background and objective: Eosinophilic gastrointestinal disorders (EGID) are a heterogeneous group of conditions, comprising eosinophilic esophagitis (EoE) and non-EoE EGID which have gained considerable research interest. There are likely to be differences in disease characteristics between populations with distinct dietary, environmental and cultural backgrounds. However much of our understanding on EGID have come from studies from Europe and North America. The aim of this review is to summarize the recent developments and updates in EGID focusing on disease phenotype specifically in Asian patients, and identify opportunities for future research pertaining to disease profile in the Asian population.

Methods: Original studies, systematic reviews, meta-analyses and review articles up to March 2024 were systematically searched on PubMed, with specific focus on newer studies published in the past 10 years. Case reports, conference abstracts and articles that were not published in the English language were excluded.

Key content and findings: Prevalence and incidence of EoE and non-EoE EGID have reportedly increased globally over time, but population-based studies are lacking in Asia. Based on heterogeneous data from a limited number of studies from Asia, there are features in epidemiology, clinical phenotype, and treatment response that may be appreciably distinct in Asian patients with EoE and non-EoE EGID, as compared to the Western patient population. Moreover, the efficacy of novel biologic therapies such as dupilumab in the Asian population has not been well-defined.

Conclusions: There is a lack of robust data on many basic aspects of EGID in Asia. There is a pressing need to bridge this gap by building research networks and collaborations across wider regions in Asia, to gather high-quality, multicenter data using standardized and uniform criteria and build a more accurate understanding of EGID in Asian patients.

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