在熟悉和陌生环境中导航时,投射到海马CA1的不同儿茶酚胺能通路传递的信号截然不同。

IF 6.4 1区 生物学 Q1 BIOLOGY eLife Pub Date : 2024-11-06 DOI:10.7554/eLife.95213
Chad Heer, Mark Sheffield
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引用次数: 0

摘要

海马的神经调节输入在调节突触可塑性、塑造神经元活动以及影响学习和记忆方面发挥着关键作用。最近的研究表明,儿茶酚胺对海马的主要来源--腹侧被盖区(VTA)和室上皮层(LC)--可能有重叠的神经递质释放和对海马的影响。因此,要剖析 VTA 和 LC 环路对海马功能的影响,就必须彻底研究这些通路如何在行为和学习过程中以不同方式运行。因此,我们利用双光子显微镜对头固定的雄性小鼠在虚拟现实(VR)环境中通过线性路径导航时海马背侧CA1区内的VTA和LC轴突活动进行了功能成像。我们发现,在熟悉的环境中,部分VTA轴突和绝大多数LC轴突与动物的奔跑速度相关。然而,当小鼠接近先前学习过的奖励位置时,绝大多数 VTA 轴突的活动逐渐增强,并在奖励位置达到峰值。与此相反,LC 轴突显示出运动前信号,预测动物从静止到运动的过渡。有趣的是,从熟悉的 VR 环境切换到新奇的 VR 环境后,出现了明显的分化。许多LC轴突的活动出现大幅增加,并在超过一分钟的时间内保持高水平,而之前观察到的VTA轴突从上升到奖励的动态在同一时期消失了。总之,这些发现突显了 VTA 和 LC 儿茶酚胺能输入在背侧 CA1 海马区的不同作用。这些输入编码了独特的信息,VTA 输入编码奖励信息,LC 输入编码新奇和运动信息,可能有助于在行为和学习过程中对海马活动进行不同的调节。
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Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments.

Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic plasticity, shaping neuronal activity, and influencing learning and memory. Recently, it has been shown that the main sources of catecholamines to the hippocampus, ventral tegmental area (VTA) and locus coeruleus (LC), may have overlapping release of neurotransmitters and effects on the hippocampus. Therefore, to dissect the impacts of both VTA and LC circuits on hippocampal function, a thorough examination of how these pathways might differentially operate during behavior and learning is necessary. We therefore utilized two-photon microscopy to functionally image the activity of VTA and LC axons within the CA1 region of the dorsal hippocampus in head-fixed male mice navigating linear paths within virtual reality (VR) environments. We found that within familiar environments some VTA axons and the vast majority of LC axons showed a correlation with the animals' running speed. However, as mice approached previously learned rewarded locations, a large majority of VTA axons exhibited a gradual ramping-up of activity, peaking at the reward location. In contrast, LC axons displayed a pre-movement signal predictive of the animal's transition from immobility to movement. Interestingly, a marked divergence emerged following a switch from the familiar to novel VR environments. Many LC axons showed large increases in activity that remained elevated for over a minute, while the previously observed VTA axon ramping-to-reward dynamics disappeared during the same period. In conclusion, these findings highlight distinct roles of VTA and LC catecholaminergic inputs in the dorsal CA1 hippocampal region. These inputs encode unique information, with reward information in VTA inputs and novelty and kinematic information in LC inputs, likely contributing to differential modulation of hippocampal activity during behavior and learning.

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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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