颈动脉中度狭窄患者髓过氧化物酶、五肽-3 和可溶性尿激酶纤溶酶原激活剂受体测定的意义。

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2024-11-07 DOI:10.1080/00365513.2024.2422404
Ana Ruzanovic, Marija Saric-Matutinovic, Neda Milinkovic, Snezana Jovicic, Andreja Dimic, David Matejevic, Ognjen Kostic, Igor Koncar, Svetlana Ignjatovic
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引用次数: 0

摘要

我们研究了颈动脉明显狭窄(CAS)50%-99% 患者血清中特定炎症参数的浓度,重点关注中度狭窄(50%-69%)患者的症状状况和斑块形态,以确定在 CAS 发展到高度狭窄之前,是否有某些参数与斑块的不稳定性有关。该研究包括 119 名 CAS 患者(其中 29 人有中度狭窄)和 46 名对照组患者。研究人员使用彩色血流多普勒和B型双工超声对颈动脉进行了超声检查,并使用市售酶免疫测定法测定了血清炎症参数。与 50-99% 狭窄的患者相比,有症状的患者只有血清淀粉样蛋白 A(SAA)较高,而在 50-69% 狭窄的患者组中,与无症状的患者相比,有症状的患者髓过氧化物酶(MPO)较高,五肽-3(PTX-3)较低,形态不稳定的颈动脉斑块患者的可溶性尿激酶纤溶酶原激活剂受体(suPAR)较高。我们的研究结果表明,不同炎症指标在中度 CAS 患者中的重要性与一般 CAS 患者不同,因此对高度和中度狭窄患者分别进行研究可能是有益的。在预测 CAS 症状风险的研究中,有可能进一步考虑 SAA。MPO和PTX-3有可能在狭窄程度较轻的斑块引发的CAS症状中发挥作用,而suPAR则参与了此类斑块的失稳。
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Significance of myeloperoxidase, pentraxin-3 and soluble urokinase plasminogen activator receptor determination in patients with moderate carotid artery stenosis.

We investigated serum concentrations of specific inflammatory parameters in patients with significant carotid artery stenosis (CAS) of 50-99%, with an additional focus on patients with moderate stenosis (50-69%), in terms of both symptomatic status and plaque morphology, to determine whether there are certain parameters that can be associated with plaque instability before the progression of CAS to a high degree. The study included 119 CAS patients, 29 of whom had moderate stenosis, and 46 controls. Ultrasonography of the carotid arteries was performed using color flow Doppler and B-mode duplex ultrasound, and serum inflammatory parameters were measured using commercially available enzyme immunoassays. When comparing patients with 50-99% stenosis, only serum amyloid A (SAA) was higher in symptomatic patients, while in the group of patients with 50-69% stenosis, myeloperoxidase (MPO) was higher and pentraxin-3 (PTX-3) was lower in symptomatic compared to asymptomatic patients, and soluble urokinase plasminogen activator receptor (suPAR) was higher in patients with carotid plaque of unstable compared to stable morphology. Our results suggest that the importance of different inflammatory parameters in patients with moderate CAS is not the same as in CAS patients in general, and therefore their separate investigation in patients with high and moderate stenosis may be beneficial. SAA has the potential to be further considered in research to predict CAS symptom risk. There is a possibility that MPO and PTX-3 play a role in the development of CAS symptoms originating from less stenotic plaques and that suPAR is involved in the destabilisation of such plaques.

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来源期刊
CiteScore
3.50
自引率
4.80%
发文量
85
审稿时长
4-8 weeks
期刊介绍: The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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