恶性黑色素瘤中 SATB2 的免疫组化表达

IF 1.3 4区医学 Q3 ANATOMY & MORPHOLOGY Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI:10.1097/PAI.0000000000001229

Rasmus Røge, Birgit Truumees, Søren Nielsen

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引用次数: 0

摘要

准确诊断原发灶不明的癌症（CUP）对病理学家来说是一项重大的日常挑战，需要可靠的免疫组化（IHC）标记物。SATB2 是一种主要在结直肠肿瘤中表达的转录因子。本研究调查了 SATB2 在恶性黑色素瘤（MM）中的 IHC 表达。利用丹麦奥尔堡大学医院的组织微阵列（TMA）（包括 56 例原发性和 12 例转移性 MM），我们通过 H 评分评估了 SATB2 的表达。我们发现，48% 的 MM 病例表达 SATB2，主要为弱至中等染色强度。虽然在原发性和转移性 MM 之间没有观察到明显的差异，但在转移性病灶中H-评分的中位数较高。这些结果凸显了SATB2在MM中表达的潜在诊断隐患，并强调了谨慎解读的必要性。

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Immunohistochemical Expression of SATB2 in Malignant Melanomas.

Accurate diagnosis of cancer of unknown primary (CUP) poses a significant daily challenge for pathologists, necessitating reliable immunohistochemical (IHC) markers. SATB2 is a transcription factor primarily expressed in colorectal neoplasms. This study investigates the IHC expression of SATB2 in malignant melanomas (MM). Using tissue microarrays (TMAs) from Aalborg University Hospital, Denmark, comprising 56 primary and 12 metastatic MMs, we evaluated SATB2 expression through H-scores. We found that 48% of MM cases expressed SATB2, predominantly with weak to moderate staining intensity. Although no significant difference was observed between primary and metastatic MMs, a higher median H-score was noted in metastatic lesions. The results highlight the potential diagnostic pitfall of SATB2 expression in MM and underline the need for careful interpretation.

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来源期刊

Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY

CiteScore

3.20

自引率

0.00%

发文量

153

期刊介绍： Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology.