Paul Loubet , Laetitia Roustand , Aurélie Schmidt , Pandora Jacquemet , Benoît de Wazières , Clémentine Vabre , Marie Nishimwe , Emmanuel Faure
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引用次数: 0
摘要
目的估计 2013 年至 2020 年期间法国带状疱疹（HZ）和带状疱疹后遗神经痛（PHN）的总体住院率，并按年龄组和免疫状况进行分层：回顾性观察数据库研究，使用法国医院出院数据库，其中包括所有日间护理和住院治疗的私人和公共数据。研究对象包括年龄≥18岁、在2013年1月1日至2020年12月31日期间住院并诊断为HZ或PHN的成年人：在观察期内，共有 62 077 名成人因诊断为 HZ 或 PHN 而首次住院。HZ和/或PHN发病率介于14.6至16.3次住院/10万人之间，年龄≥80岁者发病率最高（97.6次住院/10万人）。免疫力低下（IC）人群占研究总人数的 22%。与非 IC 患者相比，IC 患者每次因 HZ 住院的时间更长（15.5 ± 19.4 天 vs 12.2 ± 13.5 天），住院死亡率更高（8% vs 4%）。IC患者与非IC患者的人均年住院费用更高（8018欧元对5603欧元）：结论：年龄越大，住院率最高会增加 6 倍，而 IC 患者的住院死亡率最高会增加 2 倍。
Clinical profile of herpes zoster-related hospitalizations and complications: A French population-based database study
Objective
To estimate the incidence of hospitalization with a diagnosis of herpes zoster (HZ) and post-herpetic neuralgia (PHN) in France between 2013 and 2020, overall and stratified by age-group and immune status.
Methods
Retrospective observational, database study, using the French hospital discharge database, which includes private and public data for all day-care and inpatient stays. Adults aged ≥18 years, hospitalized between January 1, 2013, and December 31, 2020, with a diagnosis of HZ or PHN, were included.
Results
Overall, 62 077 adults had a first hospitalization with a diagnosis of HZ or PHN during the observation period. HZ and/or PHN incidence ranged between 14.6 and 16.3 hospitalizations/100 000 persons and was highest in people aged ≥80 years (97.6 hospitalizations/100 000 persons).
The immunocompromised (IC) population accounted for 22% of the overall study population. IC patients had longer lengths of stay for HZ per episode compared with non-IC patients (15.5 ± 19.4 days vs 12.2 ± 13.5 days) and higher in-patient mortality (8% vs 4%).
Average annual hospitalization costs per patient were higher in the IC vs non-IC population (€8018 vs €5603).
Conclusions
Older age increases hospitalization rates up to 6-fold and IC status increases in-patient mortality up to two-fold.
Clinical Trial Registration
The study was conducted by HEVA and data were provided by ATIH according to French regulatory and data protection procedures.
期刊介绍：
The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection.
Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.
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