Mef2d：2型过敏性肺部炎症中的新型转录因子

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Inorganic Chemistry Pub Date : 2024-11-07 DOI:10.1038/s41392-024-02022-9

Laura Surace, Christoph Wilhelm, Christian Bode

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引用次数: 0

摘要

最近，Szeto 等人在《科学》（Science）杂志上发表文章，指出肌细胞特异性增强因子 2d（Mef2d）是 2 型免疫和过敏性肺部炎症的启动子。作者利用 CRISPR 筛选和正交重组酶驱动的布尔基因回路，发现 Mef2d 通过抑制 Regnase-1 来调节 GATA3 的表达，从而促进 IL-33 信号传导和细胞因子的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mef2d: a novel transcription factor in type 2 allergic lung inflammation

In a recent article published in Science, Szeto et al. identified myocyte-specific enhancer factor 2d (Mef2d) as a promoter of type 2 immunity and allergic lung inflammation. Using CRISPR screens and orthogonal recombinase-enabled Boolean gene circuitry, the authors revealed that Mef2d modulates GATA3 expression by suppressing Regnase-1, thereby boosting IL-33 signaling and cytokine production.¹

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.