评估葡萄糖失调小纤维神经病变中的角膜树突状细胞。

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY Journal of the Peripheral Nervous System Pub Date : 2024-11-12 DOI:10.1111/jns.12671

Juan Francisco Idiaquez, Carolina Barnett-Tapia, Bruce A Perkins, Vera Bril

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引用次数: 0

摘要

背景和目的：小纤维神经病变（SFN）与葡萄糖失调有关，包括糖耐量受损（IGT）和 2 型糖尿病（T2D）。角膜共聚焦显微镜（CCM）是评估角膜神经损伤和树突状细胞密度（DCD）的非侵入性工具。在这项研究中，我们调查了 SFN 和血糖失调（定义为 IGT 或 T2D）患者的角膜 DCD：我们招募了 38 名 SFN + 血糖失调患者、51 名 SFN + 非血糖失调患者和 20 名健康对照者。所有参与者均接受了神经系统检查、神经电生理学检查和CCM检查：结果：与健康对照组相比，SFN 和血糖失调患者的 DCD 更高（P = .01），IGT SFN 患者的成熟 DCD 比 T2D 患者更高：与对照组和已确诊的 T2D 患者相比，IGT 患者的 DCD 较高，这可能表明 DCD 是早期神经病变的生物标志物。

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Assessing corneal dendritic cells in glucose dysregulation small-fibre neuropathy.

Background and aims: Small-fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non-invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study, we investigated corneal DCD in patients with SFN and glucose dysregulation, defined as IGT or T2D.

Methods: We enrolled 38 patients with SFN + glucose dysregulation, 51 with SFN + non-glucose dysregulation and 20 healthy controls. All participants underwent neurological examination, neurophysiology and CCM.

Results: Individuals with SFN and glucose dysregulation had higher DCD compared with healthy controls (p = .01), and mature DCD was higher in IGT SFN patients than in T2D patients.

Interpretation: Higher DCD in IGT compared with controls and patients with established T2D may suggest that DCD is a biomarker of early neuropathy.

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来源期刊

Journal of the Peripheral Nervous System 医学-临床神经学

CiteScore

6.10

自引率

7.90%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of the Peripheral Nervous System is the official journal of the Peripheral Nerve Society. Founded in 1996, it is the scientific journal of choice for clinicians, clinical scientists and basic neuroscientists interested in all aspects of biology and clinical research of peripheral nervous system disorders. The Journal of the Peripheral Nervous System is a peer-reviewed journal that publishes high quality articles on cell and molecular biology, genomics, neuropathic pain, clinical research, trials, and unique case reports on inherited and acquired peripheral neuropathies. Original articles are organized according to the topic in one of four specific areas: Mechanisms of Disease, Genetics, Clinical Research, and Clinical Trials. The journal also publishes regular review papers on hot topics and Special Issues on basic, clinical, or assembled research in the field of peripheral nervous system disorders. Authors interested in contributing a review-type article or a Special Issue should contact the Editorial Office to discuss the scope of the proposed article with the Editor-in-Chief.