雌三醇在形成单核细胞耐受性特征方面的作用。

IF 2.9 3区医学 Q3 IMMUNOLOGY Journal of Reproductive Immunology Pub Date : 2024-11-08 DOI:10.1016/j.jri.2024.104390

Irina Nekrasova, Sergei Shirshev

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引用次数: 0

摘要

雌三醇（E3）是一种激素，其合成主要与怀孕有关。这种激素还能调节免疫细胞的功能。本研究探讨了雌三醇对单核细胞吲哚胺-2,3-二氧化酶（IDO1）活性以及 Treg 和 NK 细胞标志物表达的影响。Е3能增强LPS和IFN-γ刺激的IDO1活性，而与激素剂量无关。两种浓度的Е3都增加了CD4+Foxp3+淋巴细胞的百分比。这种激素效应是由蛋白激酶 A 介导的。由于Е3 的影响，NK 细胞的 CD16 表达减少。这些数据表明，Е3是维持孕期免疫耐受和保护胎儿的因素之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Estriol in formation of mononuclear cells tolerogenic features

Estriol (E₃) is one of hormones whose synthesis is mainly associated with pregnancy. The hormone can also regulate immune cells functions. E₃ influence on monocyte indoleamine-2,3-dioxygenase (IDO1) activity and Treg and NK cells’ markers expression was investigated. LPS and IFN-γ stimulated IDO1 activity was augmented by Е₃ independently of the hormone doses. Both Е₃ concentrations increased CD4⁺Foxp3⁺ lymphocytes percentage. This hormonal effect was mediated by protein kinase A. CD16 expression upon NK cells was reduced as a result of Е₃ influence. The data indicated that Е₃ is one of the factors which maintained immune tolerance during pregnancy and protected fetus preservation.

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来源期刊

Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.30

自引率

5.90%

发文量

162

审稿时长

10.6 weeks

期刊介绍： Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology. This encompasses normal and pathological processes of: * Male and Female Reproductive Tracts * Gametogenesis and Embryogenesis * Implantation and Placental Development * Gestation and Parturition * Mammary Gland and Lactation.