通过 Pd(II)-Catalyzed Dual N-H/C Annulative-Cyclization 级联合成呋喃并吡咯并吡啶。

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemistry - A European Journal Pub Date : 2024-11-18 DOI:10.1002/chem.202403470

Hirendra Nath Dhara, Supriya Manna, Bhisma K Patel

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引用次数: 0

摘要

在钯(II)催化下，通过双环化作用，从 b-ketodinitriles 和 buta-1,3-diynes 合成了呋喃并[2,3-b]吡咯并[2,3-d]吡啶。由于两个腈（-CN）基团的参与，在一次反应中同时生成了三个杂环，即呋喃、吡咯和吡啶，形成了 C-C、C=C、C-O、C-N 和 C=N 键。通过一些合成后操作，进一步证明了该方案的合成实用性。

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A Cascade Synthesis of Furo-Pyrrolo-Pyridines via Pd(II)-Catalyzed Dual N-H/C Annulative-Cyclization.

A Pd(II)-catalyzed non-template synthesis of furo[2,3-b]pyrrolo[2,3-d]pyridines from b-ketodinitriles and buta-1,3-diynes has been accomplished via dual annulative cyclization. The participation of both the nitrile (-CN) groups led to the concurrent construction of three heterocycles viz. furan, pyrrole, and pyridine forming C-C, C=C, C-O, C-N, and C=N bonds in one pot. The synthetic utility of the protocol was further demonstrated through a few post-synthetic manipulations.

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.