Front Cover: Heteroaryl Group Containing Trisubstituted Alkenes: Synthesis and Anti-Tumor Activity (Chem. Biodiversity 11/2024)

Front Cover. The design and synthesis of molecules with anti-tumor activity are of paramount importance in the field of medicinal chemistry. Multi-substituted alkenes and heterocyclic compounds represent two scaffolds that demonstrate significant anti-tumor properties. By integrating hetero-aromatic rings into the multi-substituted alkene framework, a series of novel bioactive molecules can be developed. In article number e202401469, Meng-Yao Li and co-workers synthesized a variety of trisubstituted alkenes incorporating nitrogen, oxygen, and sulfur atoms, and subsequently evaluated their in vitro activities against gallbladder and pancreatic cancers (see 10.1002/cbdv.202401469).