类风湿性关节炎与罹患血液系统恶性肿瘤的风险:一项全国性队列研究

IF 12.8 1区 医学 Q1 HEMATOLOGY Leukemia Pub Date : 2024-11-22 DOI:10.1038/s41375-024-02477-3
In Young Cho, Kyungdo Han, Jin Hyung Jung, Mi Hee Cho, Dagyeong Lee, Keun Hye Jeon, Dong Wook Shin
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引用次数: 0

摘要

类风湿性关节炎(RA)的自身免疫和炎症发病机制、免疫调节疗法的使用以及RA与恶性肿瘤之间共同的环境或遗传风险因素已引起人们对RA患者癌症风险的关注[1],尤其是血液系统恶性肿瘤[1, 2]。在RA患者中,自身抗体的存在与疾病的快速进展有关;然而,血清阳性是否与血液系统恶性肿瘤有关尚不清楚。此外,以往对RA患者血液系统恶性肿瘤风险的研究大多报告了标准化发病率比(SIR)[1,2,3,4,5,6],缺乏对吸烟、饮酒和社会经济状况等混杂因素的考虑。有关亚洲人群的数据也很有限,尤其是白血病和多发性骨髓瘤(MM)。由于遗传和环境因素的影响,西方和亚洲人血液恶性肿瘤的发病率和病理生理学类型可能有所不同;例如,霍奇金淋巴瘤(HL)在西欧的发病率高于东亚[7]。
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来源期刊
Leukemia
Leukemia 医学-血液学
CiteScore
18.10
自引率
3.50%
发文量
270
审稿时长
3-6 weeks
期刊介绍: Title: Leukemia Journal Overview: Publishes high-quality, peer-reviewed research Covers all aspects of research and treatment of leukemia and allied diseases Includes studies of normal hemopoiesis due to comparative relevance Topics of Interest: Oncogenes Growth factors Stem cells Leukemia genomics Cell cycle Signal transduction Molecular targets for therapy And more Content Types: Original research articles Reviews Letters Correspondence Comments elaborating on significant advances and covering topical issues
期刊最新文献
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