Miranda Hawley , Joe Smith , Kaitlyn Lawson , Jocelyn Jansen , Rex Crawford , Afolakemi Adeniji , Cathy Bauman
{"title":"奶山羊牛奶中磺胺多辛消耗试验和 Charm 快速一步检测法 (ROSA) SULF 检测的诊断准确性","authors":"Miranda Hawley , Joe Smith , Kaitlyn Lawson , Jocelyn Jansen , Rex Crawford , Afolakemi Adeniji , Cathy Bauman","doi":"10.3168/jdsc.2024-0559","DOIUrl":null,"url":null,"abstract":"<div><div>In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and septicemias. The aim of this study was to determine the trimethoprim sulfadoxine withdrawal time and evaluate the test accuracy of the Charm Rapid One Step Assay (ROSA) SULF test (Charm Sciences Inc.) at the individual goat level. The study was conducted on 20 visibly healthy Ontario dairy goats. They received trimethoprim sulfadoxine at a dose of 16 mg/kg i.m. once a day for 5 d as the commercially available preparation trimethoprim sulfadoxine (Borgal, Merck Animal Health). Residue levels were measured using liquid chromatography-tandem mass spectrometry and the Charm ROSA SULF. The withdrawal time was calculated using safe concentration linear regression. The determined milk withdrawal time was 60 h.</div></div>","PeriodicalId":94061,"journal":{"name":"JDS communications","volume":"5 6","pages":"Pages 735-739"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dairy goat sulfadoxine depletion trial in milk and diagnostic accuracy of the Charm Rapid One Step Assay (ROSA) SULF test\",\"authors\":\"Miranda Hawley , Joe Smith , Kaitlyn Lawson , Jocelyn Jansen , Rex Crawford , Afolakemi Adeniji , Cathy Bauman\",\"doi\":\"10.3168/jdsc.2024-0559\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and septicemias. The aim of this study was to determine the trimethoprim sulfadoxine withdrawal time and evaluate the test accuracy of the Charm Rapid One Step Assay (ROSA) SULF test (Charm Sciences Inc.) at the individual goat level. The study was conducted on 20 visibly healthy Ontario dairy goats. They received trimethoprim sulfadoxine at a dose of 16 mg/kg i.m. once a day for 5 d as the commercially available preparation trimethoprim sulfadoxine (Borgal, Merck Animal Health). Residue levels were measured using liquid chromatography-tandem mass spectrometry and the Charm ROSA SULF. The withdrawal time was calculated using safe concentration linear regression. The determined milk withdrawal time was 60 h.</div></div>\",\"PeriodicalId\":94061,\"journal\":{\"name\":\"JDS communications\",\"volume\":\"5 6\",\"pages\":\"Pages 735-739\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JDS communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666910224001017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JDS communications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666910224001017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dairy goat sulfadoxine depletion trial in milk and diagnostic accuracy of the Charm Rapid One Step Assay (ROSA) SULF test
In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and septicemias. The aim of this study was to determine the trimethoprim sulfadoxine withdrawal time and evaluate the test accuracy of the Charm Rapid One Step Assay (ROSA) SULF test (Charm Sciences Inc.) at the individual goat level. The study was conducted on 20 visibly healthy Ontario dairy goats. They received trimethoprim sulfadoxine at a dose of 16 mg/kg i.m. once a day for 5 d as the commercially available preparation trimethoprim sulfadoxine (Borgal, Merck Animal Health). Residue levels were measured using liquid chromatography-tandem mass spectrometry and the Charm ROSA SULF. The withdrawal time was calculated using safe concentration linear regression. The determined milk withdrawal time was 60 h.
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