Hyung Joon Yoon, Tae Sik Go, Kyung Bin Kim, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim
{"title":"一名肥胖妇女因严重贫血导致踝关节骨折,并伴有大量月经出血,在骨折后意外发现子宫内膜癌:病例报告。","authors":"Hyung Joon Yoon, Tae Sik Go, Kyung Bin Kim, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim","doi":"10.3892/mco.2024.2802","DOIUrl":null,"url":null,"abstract":"<p><p>Endometrial cancer (EC) is a growing public health concern in developed countries. The incidence of EC is increasing, particularly in younger women (aged <50 years). Ankle fractures are relatively common orthopedic injuries, with the most common mechanisms being falls or trauma. A 36-year-old woman presented to the emergency department with right ankle pain secondary to a fall caused by dizziness and headache after menstruation. Initial radiography reveled a right ankle fracture without dislocation. Initial laboratory results revealed a hemoglobin level of 4.9 g/dl. She had a recent history of menorrhagia that lasted for two years. The body mass index was 36.2 kg/m<sup>2</sup>. During the evaluation, she was referred to the authors' gynecology unit after a computed tomography scan revealed a significant endometrial mass that was suspected to be EC. Magnetic resonance imaging revealed a 6.7-cm-sized endometrial mass with restricted diffusion, myometrial invasion of <1/2, and bilateral polycystic ovaries. The patient underwent open reduction and internal fixation involving screw fixation of a right ankle fracture. The postoperative follow-up showed successful healing and functional recovery. A total of 4 weeks later, robot-assisted total hysterectomy, bilateral salpingectomy and sentinel lymph node sampling were performed. Final histopathology revealed stage 1B, grade 2 endometrioid adenocarcinoma with lymphovascular space invasion. The patient received 50.4 Gy radiation to the whole pelvis. At 26 months of postoperative follow-up, the patient remained disease-free. The present case report describes a rare presentation of EC in an obese woman with heavy menstrual bleeding after ankle fracture secondary to severe anemia. The present case highlights the importance of assessing gynecological conditions through a detailed review of gynecological history with caution when an obese female patient presents with abnormal uterine bleeding, even during a non-gynecologic assessment.</p>","PeriodicalId":18737,"journal":{"name":"Molecular and clinical oncology","volume":"22 1","pages":"7"},"PeriodicalIF":1.4000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582521/pdf/","citationCount":"0","resultStr":"{\"title\":\"Endometrial cancer detected unusually after an ankle fracture secondary to severe anemia in an obese woman with heavy menstrual bleeding: A case report.\",\"authors\":\"Hyung Joon Yoon, Tae Sik Go, Kyung Bin Kim, Yong Jung Song, Dong Soo Suh, Ki Hyung Kim\",\"doi\":\"10.3892/mco.2024.2802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Endometrial cancer (EC) is a growing public health concern in developed countries. The incidence of EC is increasing, particularly in younger women (aged <50 years). Ankle fractures are relatively common orthopedic injuries, with the most common mechanisms being falls or trauma. A 36-year-old woman presented to the emergency department with right ankle pain secondary to a fall caused by dizziness and headache after menstruation. Initial radiography reveled a right ankle fracture without dislocation. Initial laboratory results revealed a hemoglobin level of 4.9 g/dl. She had a recent history of menorrhagia that lasted for two years. The body mass index was 36.2 kg/m<sup>2</sup>. During the evaluation, she was referred to the authors' gynecology unit after a computed tomography scan revealed a significant endometrial mass that was suspected to be EC. Magnetic resonance imaging revealed a 6.7-cm-sized endometrial mass with restricted diffusion, myometrial invasion of <1/2, and bilateral polycystic ovaries. The patient underwent open reduction and internal fixation involving screw fixation of a right ankle fracture. The postoperative follow-up showed successful healing and functional recovery. A total of 4 weeks later, robot-assisted total hysterectomy, bilateral salpingectomy and sentinel lymph node sampling were performed. Final histopathology revealed stage 1B, grade 2 endometrioid adenocarcinoma with lymphovascular space invasion. The patient received 50.4 Gy radiation to the whole pelvis. At 26 months of postoperative follow-up, the patient remained disease-free. The present case report describes a rare presentation of EC in an obese woman with heavy menstrual bleeding after ankle fracture secondary to severe anemia. The present case highlights the importance of assessing gynecological conditions through a detailed review of gynecological history with caution when an obese female patient presents with abnormal uterine bleeding, even during a non-gynecologic assessment.</p>\",\"PeriodicalId\":18737,\"journal\":{\"name\":\"Molecular and clinical oncology\",\"volume\":\"22 1\",\"pages\":\"7\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-11-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11582521/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and clinical oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3892/mco.2024.2802\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3892/mco.2024.2802","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Endometrial cancer detected unusually after an ankle fracture secondary to severe anemia in an obese woman with heavy menstrual bleeding: A case report.
Endometrial cancer (EC) is a growing public health concern in developed countries. The incidence of EC is increasing, particularly in younger women (aged <50 years). Ankle fractures are relatively common orthopedic injuries, with the most common mechanisms being falls or trauma. A 36-year-old woman presented to the emergency department with right ankle pain secondary to a fall caused by dizziness and headache after menstruation. Initial radiography reveled a right ankle fracture without dislocation. Initial laboratory results revealed a hemoglobin level of 4.9 g/dl. She had a recent history of menorrhagia that lasted for two years. The body mass index was 36.2 kg/m2. During the evaluation, she was referred to the authors' gynecology unit after a computed tomography scan revealed a significant endometrial mass that was suspected to be EC. Magnetic resonance imaging revealed a 6.7-cm-sized endometrial mass with restricted diffusion, myometrial invasion of <1/2, and bilateral polycystic ovaries. The patient underwent open reduction and internal fixation involving screw fixation of a right ankle fracture. The postoperative follow-up showed successful healing and functional recovery. A total of 4 weeks later, robot-assisted total hysterectomy, bilateral salpingectomy and sentinel lymph node sampling were performed. Final histopathology revealed stage 1B, grade 2 endometrioid adenocarcinoma with lymphovascular space invasion. The patient received 50.4 Gy radiation to the whole pelvis. At 26 months of postoperative follow-up, the patient remained disease-free. The present case report describes a rare presentation of EC in an obese woman with heavy menstrual bleeding after ankle fracture secondary to severe anemia. The present case highlights the importance of assessing gynecological conditions through a detailed review of gynecological history with caution when an obese female patient presents with abnormal uterine bleeding, even during a non-gynecologic assessment.