Integrating Next-Generation Evidence-Based Medicine Into Clinical Studies on Gut Microbiota Modulation.

This article explores the challenges and opportunities of applying Evidence-Based Medicine (EBM) to the field of gut microbiota research. EBM has revolutionized healthcare by integrating the best available evidence with clinical expertise and patient values. However, EBM has also faced criticisms such as overemphasizing results of randomized controlled trials and a lack of patient involvement. The article discusses these criticisms in the broader context of EBM and how they are particularly relevant to studies on gut health. This article also discusses the emergence of next-generation EBM methods, examining their potential strengths and limitations. For example, integrating next-generation EBM methods into gut microbiota studies offers the potential for improved understanding and patient-centered interventions. Still, it also raises questions about data quality, privacy, and patient involvement. This article concludes that as EBM evolves, careful attention must be paid to ensure that new methods are robust, transparent, and patient-centric, thereby contributing to better outcomes in gut microbiota research.