{"title":"磷苯碱催化的伸缩三组分反应，涉及缺电子烯的 1,1-二官能化","authors":"Azusa Kondoh , Sho Yamaguchi , Masahiro Terada","doi":"10.1039/d4cc05169f","DOIUrl":null,"url":null,"abstract":"<div><div>Phosphazene base, P2-<em>t</em>Bu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and <em>N</em>-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 2","pages":"Pages 334-337"},"PeriodicalIF":4.2000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phosphazene base-catalyzed telescopic three-component reaction involving 1,1-difunctionalization of electron-deficient alkenes†\",\"authors\":\"Azusa Kondoh , Sho Yamaguchi , Masahiro Terada\",\"doi\":\"10.1039/d4cc05169f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Phosphazene base, P2-<em>t</em>Bu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and <em>N</em>-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.</div></div>\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"61 2\",\"pages\":\"Pages 334-337\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2024-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1359734524025734\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524025734","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Phosphazene base-catalyzed telescopic three-component reaction involving 1,1-difunctionalization of electron-deficient alkenes†
Phosphazene base, P2-tBu, efficiently catalyzed the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and N-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner. The reaction involves the little-known 1,1-difunctionalization of an electron-deficient alkene, offering a new format for the three-component reaction under Brønsted base catalysis.
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