古巴生物技术的最新进展

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2024-12-11 DOI:10.1038/s41587-024-02458-y
José A. Buxadó, Miladys Limonta Fernández, Gerardo E. Guillén Nieto, Raimundo Ubieta Gómez, Marta Ayala Ávila
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引用次数: 0

摘要

古巴提供了一个低收入国家公营生物技术部门的罕见例子。自1986年成立以来,古巴的基因工程和生物技术中心(CIGB)一直监督着该国生物制药部门的发展,从药物的最初概念到临床前研究、临床试验、许可、生产和出口。我们在本刊2007年的通信中概述了CIGB的成就。我们在此更新这一叙述,以说明古巴生物技术的后续发展。CIGB继续引领癌症、传染病和其他疾病的药物和疫苗的开发,迄今已获得50多个国家的监管部门批准(表1)。值得注意的是,在COVID-19大流行的头几年,当发展中国家基本上无法获得疫苗时,CIGB基于成熟的技术生产了亚单位疫苗(CIGB 66) 2。该疫苗已获得古巴监管机构和五个外国的批准。CIGB还证明了古巴已有的静脉消炎药CIGB 258对COVID-19患者的疗效(参考文献3)。表1 CIGB的生物医学项目全尺寸表CIGB是BioCubaFarma旗下的生物技术研究所,BioCubaFarma是国有企业控股集团。大约有400名研究人员直接参与研发。CIGB的董事会考虑了一系列因素,包括国家公共卫生优先事项、内部科学专业知识、大规模生产所需的设施、对潜在专利和国外销售的市场研究,从而确定研发项目的优先顺序。项目由创新委员会协调,该委员会由与研究所、生物技术公司、大学、学术界和公共卫生部官员有关的专家组成。古巴总统参加的创新委员会每周例会旨在就研发项目达成共识。大多数项目是由科学技术和环境部批准的。卫生部确定了公共卫生优先事项,并在很大程度上反映了古巴的疾病发病率(表2)。表2古巴卫生系统2023年的前30个优先事项
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An update on Cuban biotech
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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