儿童炎症性肠病的治疗进展。

IF 3.8 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Expert Review of Gastroenterology & Hepatology Pub Date : 2024-12-01 Epub Date: 2024-12-23 DOI:10.1080/17474124.2024.2444555
Jonathan E M O'Donnell, Thomas D Walters, Eric I Benchimol
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引用次数: 0

摘要

儿童炎症性肠病(PIBD)的治疗在过去十年中发生了巨大的变化。新生物制剂或小分子疗法的有限可用性,以及对儿童持久性的担忧,使得发展其他管理方面的进步成为必要,以优化护理。涵盖领域:本综述涵盖了PIBD的管理目标指南和优化生物疗法、新医学疗法、辅助疗法、精准医学和精神健康关注方面的进展。这篇综述关注的是最近的进展,并不打算对儿科疾病的调查和管理进行全面概述。专家意见:进展包括通过治疗-靶点策略实现治疗目标的标准化,通过联合治疗或主动药物监测优化抗tnf生物制剂,克罗恩病治疗的早期开始,新生物/先进疗法的出现以及对针对微生物组的辅助治疗的日益关注。未来的进展取决于将儿童/青少年纳入临床试验,以加快儿科疗法的监管批准,并将精准医学和精神健康筛查结合起来,以改善患者护理和结果。
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Advancements in the management of pediatric inflammatory bowel disease.

Introduction: The management of pediatric inflammatory bowel disease (PIBD) has drastically changed in the last decade. The limited availability of new biologics or small molecule therapies, and concerns about durability in children has necessitated the development of other advances in management to optimize care.

Areas covered: This review covers guidance for management targets and advances in optimizing biologic therapies, new medical therapies, adjuvant therapies, precision medicine and mental health concerns in PIBD. This review focused on recent advances and was not intended as a complete overview of the investigations and management of pediatric IBD.

Expert opinion: Advancements include standardization of treatment goals via a treat-to-target strategy, optimizing anti-TNF biologics through combination therapy or proactive drug monitoring, earlier initiation of treatment for Crohn's disease, the emergence of new biologic/advanced therapies and a growing focus on adjuvant therapies targeting the microbiome. Future progress relies on the inclusion of children/adolescents in clinical trials to facilitate faster regulatory approval for pediatric therapies and the integration of precision medicine and mental health screening to improve patient care and outcomes.

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来源期刊
Expert Review of Gastroenterology & Hepatology
Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.80
自引率
2.60%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.
期刊最新文献
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