H1变异二泛基化的位置特异性点击化学方法显示位置依赖性刺激DNA修复蛋白RNF168。

Angewandte Chemie Pub Date : 2024-12-18 DOI:10.1002/ange.202485261

Pauline Franz, Charlotte M. Delvaux de Fenffe, Beat Fierz

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摘要

点击化学。在他们的研究文章（e202408435）中，Beat Fierz和他的同事们表明，环指蛋白168 （RNF168）受到二泛素化H1的刺激，这是由位点特异性点击化学方法产生的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Frontispiz: Ein ortsspezifischer Click-Chemie-Ansatz zur Diubiquitylierung von H1-Varianten zeigt eine positionsabhängige Stimulation des DNA-Reparaturproteins RNF168

Click Chemistry. In their Research Article (e202408435), Beat Fierz and co-workers show that the RING finger protein 168 (RNF168) is stimulated by di-ubiquitylated H1, which is produced by a site-specific click chemistry approach.

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来源期刊

Angewandte Chemie 化学科学, 有机化学, 有机合成

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审稿时长

1 months