Huiqiong Jia , Qingchao Tong , Le Wang , Yuye Wu , Xinyang Li , Shuangshuang Li , Yingying Kong , Yingying Zhang , João Pedro Rueda Furlan , Nwai Oo Khine , Patrick Butaye , Jun Zhang , Qing Yang , Zhi Ruan
{"title":"一株社区获得性鲍曼不动杆菌质粒携带的tet（X6）和blaOXA-58基因的沉默循环","authors":"Huiqiong Jia , Qingchao Tong , Le Wang , Yuye Wu , Xinyang Li , Shuangshuang Li , Yingying Kong , Yingying Zhang , João Pedro Rueda Furlan , Nwai Oo Khine , Patrick Butaye , Jun Zhang , Qing Yang , Zhi Ruan","doi":"10.1016/j.drup.2024.101194","DOIUrl":null,"url":null,"abstract":"<div><div>To characterize the genomic features of a community-acquired <em>Acinetobacter baumannii</em> strain, co-carrying <em>tet</em>(X6) and <em>bla</em><sub>OXA-58</sub> genes, but was susceptible to tigecycline and carbapenems. The <em>tet</em>(X6) and <em>bla</em><sub>OXA-58</sub> genes were found on a 149,518 bp non-conjugative plasmid. The <em>bla</em><sub>OXA-58</sub> gene was silent, due to the presence of an intact IS<em>Aba3</em>-like element upstream, which rendered the strain susceptible to carbapenems.</div></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":"79 ","pages":"Article 101194"},"PeriodicalIF":15.8000,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain\",\"authors\":\"Huiqiong Jia , Qingchao Tong , Le Wang , Yuye Wu , Xinyang Li , Shuangshuang Li , Yingying Kong , Yingying Zhang , João Pedro Rueda Furlan , Nwai Oo Khine , Patrick Butaye , Jun Zhang , Qing Yang , Zhi Ruan\",\"doi\":\"10.1016/j.drup.2024.101194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>To characterize the genomic features of a community-acquired <em>Acinetobacter baumannii</em> strain, co-carrying <em>tet</em>(X6) and <em>bla</em><sub>OXA-58</sub> genes, but was susceptible to tigecycline and carbapenems. The <em>tet</em>(X6) and <em>bla</em><sub>OXA-58</sub> genes were found on a 149,518 bp non-conjugative plasmid. The <em>bla</em><sub>OXA-58</sub> gene was silent, due to the presence of an intact IS<em>Aba3</em>-like element upstream, which rendered the strain susceptible to carbapenems.</div></div>\",\"PeriodicalId\":51022,\"journal\":{\"name\":\"Drug Resistance Updates\",\"volume\":\"79 \",\"pages\":\"Article 101194\"},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2024-12-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Resistance Updates\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1368764624001523\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Resistance Updates","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1368764624001523","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain
To characterize the genomic features of a community-acquired Acinetobacter baumannii strain, co-carrying tet(X6) and blaOXA-58 genes, but was susceptible to tigecycline and carbapenems. The tet(X6) and blaOXA-58 genes were found on a 149,518 bp non-conjugative plasmid. The blaOXA-58 gene was silent, due to the presence of an intact ISAba3-like element upstream, which rendered the strain susceptible to carbapenems.
期刊介绍：
Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation.
Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective.
*Expert reviews in clinical and basic drug resistance research in oncology and infectious disease
*Describes emerging technologies and therapies, particularly those that overcome drug resistance
*Emphasises common themes in microbial and cancer research
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