免疫检查点抑制剂治疗多发性硬化症患者的炎症性疾病

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2024-12-31 DOI:10.1002/acn3.52287

Saira Afzal, Yadi Li, Brittany Lapin, Le H. Hua, Lucy Boyce Kennedy, Wen Wee Ma, Marisa McGinley, Jeffrey A. Cohen, Amy Kunchok

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引用次数: 0

摘要

本研究评估了接受免疫检查点抑制剂（ICIs）治疗的多发性硬化症（PwMS）患者与未接受ICIs治疗的PwMS患者的疾病活动性。纳入108例PwMS（27例PwMS+ICIs和81例PwMS对照），年龄、性别、病程、DMTs和MS病程相匹配。在27例PwMS+ICIs中，1例（4%）复发，4例（15%）出现新的MRI病变，无临床症状。采用Kaplan-Meier曲线和Cox回归模型比较复发时间和MRI活动。与对照组相比，PwMS+ICIs患者的复发时间（p = 0.34）或MRI活性（p = 0.15）均无显著差异。

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Inflammatory disease in people with multiple sclerosis treated with immune checkpoint inhibitors

This study evaluated disease activity in people with Multiple Sclerosis (PwMS) who received immune checkpoint inhibitors (ICIs) compared to PwMS not treated with ICIs. There were 108 PwMS included (27 PwMS+ICIs and 81 PwMS controls), matched on age, sex, disease duration, DMTs, and MS disease course. Of 27 PwMS+ICIs, one (4%) had a relapse and four (15%) developed new MRI lesions without clinical symptoms. Time to relapse and MRI activity were compared using Kaplan–Meier curves and Cox regression models. There was no significant difference for either time to relapse (p = 0.34) or MRI activity (p = 0.15) in PwMS+ICIs compared to controls.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.