{"title":"pks+大肠杆菌黏附素——善与恶的界限","authors":"Chi Chun Wong, Jun Yu","doi":"10.1016/j.chom.2024.12.007","DOIUrl":null,"url":null,"abstract":"Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of <em>Nature</em>, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing <em>E. coli</em> on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.","PeriodicalId":9693,"journal":{"name":"Cell host & microbe","volume":"53 1","pages":""},"PeriodicalIF":20.6000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"pks+ E. coli adhesins—The fine line between good and evil\",\"authors\":\"Chi Chun Wong, Jun Yu\",\"doi\":\"10.1016/j.chom.2024.12.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of <em>Nature</em>, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing <em>E. coli</em> on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.\",\"PeriodicalId\":9693,\"journal\":{\"name\":\"Cell host & microbe\",\"volume\":\"53 1\",\"pages\":\"\"},\"PeriodicalIF\":20.6000,\"publicationDate\":\"2025-01-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell host & microbe\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.chom.2024.12.007\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell host & microbe","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.chom.2024.12.007","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
pks+ E. coli adhesins—The fine line between good and evil
Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E. coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.
期刊介绍：
Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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