大型语言模型的生物医学应用平台

IF 33.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2025-01-22 DOI:10.1038/s41587-024-02534-3
Sebastian Lobentanzer, Shaohong Feng, Noah Bruderer, Andreas Maier, The BioChatter Consortium, Cankun Wang, Jan Baumbach, Jorge Abreu-Vicente, Nils Krehl, Qin Ma, Thomas Lemberger, Julio Saez-Rodriguez
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引用次数: 0

摘要

近年来,生成式人工智能(AI)取得了长足的进步,尤其是在语言领域。然而,尽管其迅速商品化,其在生物医学研究中的应用仍处于起步阶段1,2。使用大型语言模型(llm)的两个主要途径是终端用户就绪的平台,通常由大型公司提供,以及由具有编程知识的个人研究人员开发的定制解决方案。这两个用例都有明显的限制。商业平台不符合可重复研究所需的透明度标准;没有一个是开源的,只有少数提供了(肤浅的)对其算法的科学描述。它们还受到隐私问题(用户数据的重用)和相当大的商业压力的影响。此外,它们不能完全定制以适应特定的研究领域或工作流程。另一方面,大多数生物医学研究人员无法获得单独的解决方案。除了研究人员的领域特定知识之外,它们还需要许多专业技能,例如编程、数据管理、机器学习知识、部署和框架方面的技术专长,以及在快速变化的环境中管理软件版本。由于涉及许多技术挑战,这反过来又阻碍了可靠和可重复的结果。因此,法学硕士在生物医学研究中的应用仍处于个案研究的水平,而成像领域则拥有几个开源的人工智能框架和批准的医疗设备1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A platform for the biomedical application of large language models
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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