蒿属植物的体外抗血吸虫活性。

IF 2.1 3区 医学 Q2 PARASITOLOGY Acta tropica Pub Date : 2025-02-01 DOI:10.1016/j.actatropica.2025.107535
Dehan Malan , Suzanne Van Niekerk , Cécile Häberli , Jennifer Keiser , Frank Van der Kooy
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In vitro antischistosomal activity of Artemisia species
Praziquantel is currently the only effective treatment for schistosomiasis, but several limitations underscore the need for new therapeutic agents. Recent promising in vitro results with Artemisia species and the success of A. annua and its active compound artemisinin in treating parasitic infections warrant the need for further studies. Here we evaluate the in vitro activity of nine Artemisia species, including previously untested species, against newly transformed schistosomula (NTS) and adult Schistosoma mansoni. Three extracts were prepared: an aqueous infusion, a dichloromethane (DCM) fraction of the aqueous infusion, and a DCM extract. All samples were tested for activity at concentrations ranging from 1–25 μg/ml against NTS and the most promising against the adult S. mansoni. All aqueous infusions showed inferior activity against NTS as opposed to the DCM fractions of the infusions and DCM extracts of A. abrotanum, A. arborescens, A. afra, and A. scoparia which displayed superior activity as compared to the positive control praziquantel. The DCM fraction infusions of A. afra (BB) were the most active with IC50 values of 0.35 μg/ml against NTS and 4.5 μg/ml against adult worms. Chemical fingerprinting using High-performance liquid chromatography (HPLC) analysis of the samples revealed some phytochemical similarities and significant differences between the species tested. This study provides supporting evidence of the antischistosomal potential of Artemisia spp. and warrants more in-depth research to identify potential novel therapeutic agents for the treatment of schistosomiasis.
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来源期刊
Acta tropica
Acta tropica 医学-寄生虫学
CiteScore
5.40
自引率
11.10%
发文量
383
审稿时长
37 days
期刊介绍: Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.
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