还原系统在蛋白质过硫化和脱硫化中的双重作用。

IF 6.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2025-01-16 DOI:10.3390/antiox14010101

Zhichao Liu, Nicolas Rouhier, Jérémy Couturier

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引用次数: 0

摘要

特定半胱氨酸残基氧化修饰成过硫化物被认为是硫化氢（H2S）发挥其生物学和信号功能的主要途径。因此，与其他可逆的氧化还原翻译后修饰一样，蛋白质过硫化是一种重要的巯基转换机制。考虑到它们的还原酶活性，以及它们与产生H2S及其相关分子的蛋白质的联系，glutaredoxin （GRX）和thioredoxin （TRX）还原系统在蛋白质过硫化和去硫化中具有潜在的双重作用。在这篇综述中，我们将首先关注描述导致蛋白质过硫化的生理途径的最新进展，然后讨论生理TRX和谷胱甘肽/ grx还原系统在蛋白质过硫化/去硫化中的双重作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation.

The oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (H₂S) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching mechanism as other reversible redox post-translational modifications. Considering their reductase activity but also their connections with proteins that generate H₂S and its related molecules, the glutaredoxin (GRX) and thioredoxin (TRX)-reducing systems have potential dual roles in both protein persulfidation and depersulfidation. In this review, we will first focus on recent advances describing the physiological pathways leading to protein persulfidation before discussing the dual roles of the physiological TRX and glutathione/GRX-reducing systems in protein persulfidation/depersulfidation.

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.