子宫内膜容受性——来自“组学”的教训。

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2025-01-11 DOI:10.3390/biom15010106

Louie Ye, Evdokia Dimitriadis

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引用次数: 0

摘要

着床窗口（window of着床，WOI）是月经周期的一个关键阶段，在此期间，子宫内膜变得可接受并有利于胚胎着床。根据基因组学、表观基因组学、转录组学、蛋白质组学、脂质组学、代谢组学和微生物组学等不同“组学”分支的研究结果，本文旨在(1)讨论子宫内膜容受性的机制见解及其在不孕症中的意义；(2)强调子宫内膜容受性的研究进展；(3)讨论可能改善生殖结果的新诊断和治疗策略。

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Endometrial Receptivity-Lessons from "Omics".

The window of implantation (WOI) is a critical phase of the menstrual cycle during which the endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches of "omics", including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review aims to (1) discuss mechanistic insights on endometrial receptivity and its implication in infertility; (2) highlight advances in investigations for endometrial receptivity; and (3) discuss novel diagnostic and therapeutic strategies that may improve reproductive outcomes.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.