ALS临床试验数据库中直立性低血压的频率。

IF 3.3 3区医学 Q2 CLINICAL NEUROLOGY Frontiers in Neurology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI:10.3389/fneur.2025.1512357

C Quarracino, F Capani, M Otero-Losada, G E Rodríguez, S Pérez-Lloret

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引用次数: 0

摘要

目的：探讨大样本肌萎缩性侧索硬化症（ALS）患者体位性低血压（OH）的发生频率。方法：从PRO-ACT数据库中对1240例ALS患者的数据进行分析，重点分析站立前后的血压和心率。OH被定义为站立后3 分钟内收缩压/舒张压 > 20/10 mm Hg下降。当未服用可能影响这种反应的药物的患者心率增加低于15 bpm时，诊断为神经源性OH。结果：基线时，138例（11.1%）患者出现OH，其中76.1%为神经源性OH。随访时，163例患者（13.1%）有OH， 71.2%为神经源性OH。只有22.5%的基线OH患者在随访时出现OH。结论：在ALS患者的大样本中，OH发生率为11-13%，这表明该亚组可能需要特殊护理以避免相关并发症。

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Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database.

Purpose: To explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).

Methods: From the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before and after standing. OH was defined as a drop in systolic/diastolic blood pressure > 20/10 mm Hg within 3 min of standing. Neurogenic OH was diagnosed when the heart rate increase was below 15 bpm in patients not taking medications that could affect this response.

Results: At baseline, 138 (11.1%) patients showed OH, 76.1% of whom had neurogenic OH. At follow-up, 163 patients (13.1%) had OH, 71.2% with neurogenic OH. Only 22.5% of the patients with OH at baseline had OH at follow-up.

Conclusion: In a large sample of ALS patients, OH occurred in 11-13%, pointing to a subgroup that might require special care to avoid related complications.

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来源期刊

Frontiers in Neurology CLINICAL NEUROLOGYNEUROSCIENCES -NEUROSCIENCES

CiteScore

4.90

自引率

8.80%

发文量

2792

审稿时长

14 weeks

期刊介绍： The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.