新肺炎球菌疫苗的潜在效力

Q4 Medicine Journal de Pediatrie et de Puericulture Pub Date : 2024-12-01 Epub Date: 2024-12-19 DOI:10.1016/S0987-7983(24)00158-0

R. Cohen , C. Levy , E. Varon

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引用次数: 0

摘要

在儿童中实施肺炎球菌结合疫苗（PCV7和PCV13）已导致疫苗型肺炎球菌感染的急剧减少，并通过群体免疫对成人产生额外益处。然而，血清型3、19A和19F在儿童中的水平仍然很低，而新的非疫苗血清型（NVTs）现在在IPD中占主导地位。在欧洲批准的新型肺炎球菌疫苗中，PCV20覆盖了40%以上的侵袭性分离株，而PCV15覆盖不到10%。一些nvt，如24F，不包括在PCV20中，仍然存在问题。未来疫苗的选择将取决于它们覆盖这些替代血清型的能力。©2024作者。Elsevier Masson SAS出版。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spectre potentiel d'activité des nouveaux vaccins contre le pneumocoque

The implementation of pneumococcal conjugate vaccines (PCV7 and PCV13) in children has led to a dramatic reduction in vaccine-type pneumococcal infections, with additional benefits for adults through herd immunity. However, serotypes 3, 19A, and 19F persist at low levels in children, and new non-vaccine serotypes (NVTs) now predominate in IPD. Among the new pneumococcal vaccines approved in Europe, PCV20 covers more than 40% of invasive isolates, compared to less than 10% for PCV15. Some NVTs like 24F, not included in PCV20, remain problematic. The choice of future vaccines will depend on their ability to cover these replacement serotypes.

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来源期刊

Journal de Pediatrie et de Puericulture Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.10

自引率

0.00%

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期刊介绍： Les articles du Journal de pédiatrie et de puériculture traitent en profondeur tous les aspects des soins à enfant dont la diversité est à image de ces professions aux rôles multiples. Les sujets traités couvrent le traitement et les soins aux enfants malades, le conseil génétique, ainsi que les techniques de pointe : nouvelles approches du diagnostic prénatal, génie génétique, etc. Les disciplines concernées sont nombreuses : pédiatrie générale, médecine fœtale et néonatale, nutrition, dermatologie, pharmacologie, psychiatrie et psychologie, puériculture pratique, enfant et société, nouvelles des congrès.