1,3-苯二唑衍生咪唑和吡啶类离子液体的抗菌评价

Journal of Ionic Liquids Pub Date : 2025-06-01 Epub Date: 2025-01-13 DOI:10.1016/j.jil.2024.100130
Sagar Panchal , Hitesh Sehrawat , Nisha Yadav , Shipra Chandra , Vivek Mishra , Neera Sharma , Ramesh Chandra
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引用次数: 0

摘要

1,3-苯二唑是一种重要的生物活性成分,在许多天然产物中含量丰富。本研究利用不同的氟化物合成了1,3-苯二唑类离子液体,并评价了它们对革兰氏阴性(-)型大肠杆菌和革兰氏阳性(+)型金黄色葡萄球菌的抑菌性能。在本报告中,我们报道了不同组合的MIC(最小抑制剂浓度)和ZOI(抑制区)分析,并将最佳组合进一步用于原子水平上相互作用的计算机计算研究。
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Anti-Bacterial evaluation of 1,3-Benzodioxole derived imidazolium and pyridinium based ionic liquids
1,3-benzodioxole is one prominent biological active moiety which is abundant in numerous natural products. In this work we have synthesized 1,3-benzodioxole based ionic liquids using the different fluorides and have evaluated their anti-bacterial properties on Gram negative (-) Escherichia coli and Gram positive (+) Staphylococcus aureus bacterial strains were assessed. In this report we have reported the MIC (minimum inhibitor concentration) and ZOI (zone of inhibition) analysis of the different combinations and the best combination was the further used for the in-silico computational study for the interaction at the atomic level.
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