Pleural small cell carcinoma: A case report.

Abstract: Small cell carcinoma (SCC) is most commonly found in the lung. Extrapulmonary SCC has been reported in various organs. Despite its rarity, primary pleural SCC should be considered along with mesothelioma in the case of a pleura-based mass because of the difference in prognosis and treatment. To highlight the role of morphology and IHC in arriving at a diagnosis of primary pleural SCC. Pleural biopsy with its hematoxylin and eosin-stained and immunohistochemistry slides. Tumor cells were immunoreactive for synaptophysin, chromogranin, CK7, TTF1, and BerEP4, along with focal reactivity for calretinin. The cells were negative for CK5/6, WT1, and mesothelin. A detailed morphological examination plays an important role in ruling out all the tumors displaying small cell features at this site, and a limited IHC panel can aid in arriving at a diagnosis of primary pleural SCC.