Difficulties in Using Natural Herbal Substances and Their Current use in Some Pharmaceutical Dosage Forms.

Aim: Random use of natural herbal products affects the treatment of diseases. In this review, the limitations may be encountered in using natural substances of plant origin and the studies on using these substances in treating cancer, cognitive disorders, heart diseases, diabetes, and microbial diseases are examined and summarized.

Background: People worldwide use herbal products derived from natural plants to solve health problems. It is known that random use of herbal products can negatively affect the treatment. However, people need help with the formulation or use of natural substances. There is no new disease-modifying herbal therapy available to treat diseases such as cancer, microbial disorders, diabetes, cognitive disorders, and cardiac disorders.

Objective: This review aims to report the difficulties encountered in formulating and using natural herbal substances and highlight their possible use in some diseases.

Materials and methods: Available information about the study was collected through many search engines such as Science Direct, PubMed, and Google Scholar.

Results: Working with natural herbal substances worldwide presents many difficulties, especially a lack of knowledge, modern technological devices, or clinical studies. According to currently available studies, some natural herbal substances are effective against cancer, microbial disorders, diabetes, cognitive disorders, and heart disorders.

Conclusion: Deepening the studies would be benefical in eliminating the difficulties related to natural herbal medicines and making them more reliable. More research is needed to include these substances in the protocol and use them in treating diseases.