{"title":"薯蓣皂苷的最新研究进展：药理学、药代动力学和毒理学分析。","authors":"Bhoopendra Singh, Bhupesh C Semwal, Sonia Singh","doi":"10.2174/0115680266355377250213054844","DOIUrl":null,"url":null,"abstract":"<p><p>Diosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis. It has been shown that diosmetin has pharmacological actions that include neuroprotective, antioxidant, and anticancer properties. The objective of this manuscript is to provide a comprehensive review of the pharmacological, pharmacokinetic, and toxicological profile of diosmetin. The information has been collected from several research papers found in various databases, including Web of Science, Pubmed, Scopus, and ScienceDirect. Diosmetin has the potential to reduce inflammation, and it can also improve vascular functions and protect against oxidative stress, both of which are essential for the prevention and management of several diseases.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":"2100-2113"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile.\",\"authors\":\"Bhoopendra Singh, Bhupesh C Semwal, Sonia Singh\",\"doi\":\"10.2174/0115680266355377250213054844\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis. It has been shown that diosmetin has pharmacological actions that include neuroprotective, antioxidant, and anticancer properties. The objective of this manuscript is to provide a comprehensive review of the pharmacological, pharmacokinetic, and toxicological profile of diosmetin. The information has been collected from several research papers found in various databases, including Web of Science, Pubmed, Scopus, and ScienceDirect. Diosmetin has the potential to reduce inflammation, and it can also improve vascular functions and protect against oxidative stress, both of which are essential for the prevention and management of several diseases.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"2100-2113\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266355377250213054844\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266355377250213054844","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
薯蓣皂苷，也被称为3′，5,7 -三羟基-4′-甲氧基黄酮，是一种生物类黄酮，可以在几种食物来源中找到。这些主要包括柑橘类水果和植物，如迷迭香、柑橘、枸杞和蔷薇。研究表明，薯蓣皂苷具有神经保护、抗氧化和抗癌等药理作用。本文的目的是提供一个全面的药理学，药代动力学和毒理学概况薯蓣皂苷的审查。这些信息是从不同数据库中发现的几篇研究论文中收集的，包括Web of Science、Pubmed、Scopus和ScienceDirect。薯蓣皂苷具有减少炎症的潜力，它还可以改善血管功能和防止氧化应激，这两者对于预防和治疗几种疾病都是必不可少的。
Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile.
Diosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis. It has been shown that diosmetin has pharmacological actions that include neuroprotective, antioxidant, and anticancer properties. The objective of this manuscript is to provide a comprehensive review of the pharmacological, pharmacokinetic, and toxicological profile of diosmetin. The information has been collected from several research papers found in various databases, including Web of Science, Pubmed, Scopus, and ScienceDirect. Diosmetin has the potential to reduce inflammation, and it can also improve vascular functions and protect against oxidative stress, both of which are essential for the prevention and management of several diseases.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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