病原体基因组学国家投资案例开发。

IF 11.1 Q1 CELL BIOLOGY Cell genomics Pub Date : 2025-02-21 DOI:10.1016/j.xgen.2025.100781
Yoong Khean Khoo, Suci Wulandari, Marya Getchell, La Moe, Shurendar Selva Kumar, Elyssa Jiawen Liu, Yimei Sun, Junxiong Pang, Swapnil Mishra, Hannah Clapham, Ben Marais, Vitali Sintchenko, Ruklanthi de Alwis, David Hipgrave, Paul Michael Pronyk
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National investment case development for pathogen genomics.

Sustaining and expanding genomic surveillance capacity requires broader investment in genomics that target both novel and pandemic pathogens. Currently, there is no standardized methodology to evaluate the cost and benefit of a multi-pathogen surveillance system. We propose a framework for pathogen genomic surveillance that links public health and systems considerations to a stepwise approach.

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Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity. Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM. Capturing cell-type-specific activities of cis-regulatory elements from peak-based single-cell ATAC-seq. A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans. National investment case development for pathogen genomics.
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