Qiaowen Wang, Xiao Huang, Dingjun Wang, Biying Zhong, Mengyuan Xu, Li Liu, Tiantian Liu
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Characterization of MIL-101(Fe)-PA was carried out using scanning electron microscopy(SEM), Fourier transform infrared(FT-IR) spectroscopy,X-ray diffractometer (XRD) and Brunauer-Emmett-Teller (BET) adsorption analysis. In the bacteriostatic experiments,its bacteriostatic effect was investigated by Minimal inhibitory concentration (MIC) experiments, cell proliferation,and growth curves of bacteria. Then its cytotoxicity was explored by cytotoxicity experiments.</div></div><div><h3>Results</h3><div>The characterization results indicated that we successfully prepared the complex MIL-101(Fe)-PA,which showed significant bacteriostatic effects against <em>S. aureus</em> and <em>E. coli</em> at 2 mg/mL. The inhibitory effect was stronger than that of MIL-101(Fe) as well as PA.</div></div><div><h3>Conclusion</h3><div>It shows that MIL-101(Fe)-PA has excellent inhibitory effect on <em>S. aureus</em> and <em>E. coli.</em></div></div>","PeriodicalId":18599,"journal":{"name":"Microbial pathogenesis","volume":"203 ","pages":"Article 107460"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and characterization of MIL-101(Fe) nanoparticle and Patchouli alcohol composites as a antimicrobial agents\",\"authors\":\"Qiaowen Wang, Xiao Huang, Dingjun Wang, Biying Zhong, Mengyuan Xu, Li Liu, Tiantian Liu\",\"doi\":\"10.1016/j.micpath.2025.107460\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Multidrug-resistant <em>Staphylococcus aureus (S. aureus)</em> and <em>Escherichia coli (E. coli)</em> are emerging in large numbers, while the rapid development of antimicrobial nanomaterials offers new opportunities to combat bacterial infections and antimicrobial resistance.</div></div><div><h3>Objectives</h3><div>We employed the nanomaterial MIL-101(Fe) as a carrier loaded with Patchouli alcohol (PA) to form the complex MIL-101(Fe)-PA. and to investigate the inhibitory activity of MIL-101(Fe)-PA against <em>S. aureus</em> and <em>E. coli</em>.</div></div><div><h3>Methods</h3><div>According to the literature,we prepared MIL-101(Fe)-PA by solvent method. Characterization of MIL-101(Fe)-PA was carried out using scanning electron microscopy(SEM), Fourier transform infrared(FT-IR) spectroscopy,X-ray diffractometer (XRD) and Brunauer-Emmett-Teller (BET) adsorption analysis. In the bacteriostatic experiments,its bacteriostatic effect was investigated by Minimal inhibitory concentration (MIC) experiments, cell proliferation,and growth curves of bacteria. Then its cytotoxicity was explored by cytotoxicity experiments.</div></div><div><h3>Results</h3><div>The characterization results indicated that we successfully prepared the complex MIL-101(Fe)-PA,which showed significant bacteriostatic effects against <em>S. aureus</em> and <em>E. coli</em> at 2 mg/mL. The inhibitory effect was stronger than that of MIL-101(Fe) as well as PA.</div></div><div><h3>Conclusion</h3><div>It shows that MIL-101(Fe)-PA has excellent inhibitory effect on <em>S. aureus</em> and <em>E. coli.</em></div></div>\",\"PeriodicalId\":18599,\"journal\":{\"name\":\"Microbial pathogenesis\",\"volume\":\"203 \",\"pages\":\"Article 107460\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbial pathogenesis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0882401025001858\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial pathogenesis","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0882401025001858","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Synthesis and characterization of MIL-101(Fe) nanoparticle and Patchouli alcohol composites as a antimicrobial agents
Background
Multidrug-resistant Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are emerging in large numbers, while the rapid development of antimicrobial nanomaterials offers new opportunities to combat bacterial infections and antimicrobial resistance.
Objectives
We employed the nanomaterial MIL-101(Fe) as a carrier loaded with Patchouli alcohol (PA) to form the complex MIL-101(Fe)-PA. and to investigate the inhibitory activity of MIL-101(Fe)-PA against S. aureus and E. coli.
Methods
According to the literature,we prepared MIL-101(Fe)-PA by solvent method. Characterization of MIL-101(Fe)-PA was carried out using scanning electron microscopy(SEM), Fourier transform infrared(FT-IR) spectroscopy,X-ray diffractometer (XRD) and Brunauer-Emmett-Teller (BET) adsorption analysis. In the bacteriostatic experiments,its bacteriostatic effect was investigated by Minimal inhibitory concentration (MIC) experiments, cell proliferation,and growth curves of bacteria. Then its cytotoxicity was explored by cytotoxicity experiments.
Results
The characterization results indicated that we successfully prepared the complex MIL-101(Fe)-PA,which showed significant bacteriostatic effects against S. aureus and E. coli at 2 mg/mL. The inhibitory effect was stronger than that of MIL-101(Fe) as well as PA.
Conclusion
It shows that MIL-101(Fe)-PA has excellent inhibitory effect on S. aureus and E. coli.
期刊介绍：
Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports.
Research Areas Include:
-Pathogenesis
-Virulence factors
-Host susceptibility or resistance
-Immune mechanisms
-Identification, cloning and sequencing of relevant genes
-Genetic studies
-Viruses, prokaryotic organisms and protozoa
-Microbiota
-Systems biology related to infectious diseases
-Targets for vaccine design (pre-clinical studies)
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