{"title":"外泌体介导的凝集素途径和抵抗素- mif - aa代谢轴驱动免疫性血小板减少症的免疫功能障碍（add . Sci. 10/2025）","authors":"Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo","doi":"10.1002/advs.202570066","DOIUrl":null,"url":null,"abstract":"<p><b>Immune Thrombocytopenia</b></p><p>The exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells. The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses- akin to insurgents in hot-air balloons igniting rampant fires across a lightly guarded industrial zone, ultimately unleashing toxic chemical leaks. More details can be found in article number 2412378 by Rongqun Guo, Yong Jiang, Yanxia Gao, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 10","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570066","citationCount":"0","resultStr":"{\"title\":\"Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)\",\"authors\":\"Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo\",\"doi\":\"10.1002/advs.202570066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Immune Thrombocytopenia</b></p><p>The exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells. The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses- akin to insurgents in hot-air balloons igniting rampant fires across a lightly guarded industrial zone, ultimately unleashing toxic chemical leaks. More details can be found in article number 2412378 by Rongqun Guo, Yong Jiang, Yanxia Gao, and co-workers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":\"12 10\",\"pages\":\"\"},\"PeriodicalIF\":14.1000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570066\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570066\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570066","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)
Immune Thrombocytopenia
The exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells. The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses- akin to insurgents in hot-air balloons igniting rampant fires across a lightly guarded industrial zone, ultimately unleashing toxic chemical leaks. More details can be found in article number 2412378 by Rongqun Guo, Yong Jiang, Yanxia Gao, and co-workers.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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