在体内,马桑素通过激活SIRT1/p53/SLC7A11信号通路减轻铁下垂,从而减轻糖尿病性心肌病。

Qingmei Wang, Xuanguo Zhang, Li Xi
{"title":"在体内,马桑素通过激活SIRT1/p53/SLC7A11信号通路减轻铁下垂,从而减轻糖尿病性心肌病。","authors":"Qingmei Wang, Xuanguo Zhang, Li Xi","doi":"10.1055/a-2557-4592","DOIUrl":null,"url":null,"abstract":"<p><p>The article Morin Attenuates Ferroptosis via Activation of the SIRT1/p53/SLC7A11 Signaling Pathway to Alleviate Diabetic Cardiomyopathy In Vivo, by Qingmei Wang, Xuanguo Zhang and Li Xi, published online on March 12, 2025 has been retracted by the Editor-in-Chief and the Publisher. Following an internal investigation by the Publisher, irregularities with respect to the submission and peer review were found. Consequently, the Editor-in-Chief therefore no longer has confidence in the results and conclusions presented in the article. The authors do not agree with this retraction.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retraction Note: Morin attenuates ferroptosis via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate diabetic cardiomyopathy in vivo.\",\"authors\":\"Qingmei Wang, Xuanguo Zhang, Li Xi\",\"doi\":\"10.1055/a-2557-4592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The article Morin Attenuates Ferroptosis via Activation of the SIRT1/p53/SLC7A11 Signaling Pathway to Alleviate Diabetic Cardiomyopathy In Vivo, by Qingmei Wang, Xuanguo Zhang and Li Xi, published online on March 12, 2025 has been retracted by the Editor-in-Chief and the Publisher. Following an internal investigation by the Publisher, irregularities with respect to the submission and peer review were found. Consequently, the Editor-in-Chief therefore no longer has confidence in the results and conclusions presented in the article. The authors do not agree with this retraction.</p>\",\"PeriodicalId\":94001,\"journal\":{\"name\":\"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2557-4592\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2557-4592","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

糖尿病性心肌病(DCM)是糖尿病患者的严重并发症,目前仍缺乏适当的治疗。上睑下垂最近被强调为DCM发展的主要贡献者。因此,本研究旨在评估桑辣素(一种众所周知的植物化学物质)对DCM的影响。为此,采用链脲佐菌素(STZ)诱导Wistar大鼠DCM。给动物口服25、50、100 mg/kg桑肽60 d后,测定心脏组织中SIRT1 (SIRT1)、p53、溶质载体家族7成员11 (SLC7A11)和谷胱甘肽过氧化物酶4 (GPX4)的基因和蛋白水平。此外,测定心脏组织中的氧化还原状态(GSH、SOD、CAT和MDA)和炎症标志物(IL-6、IL-1和TNF-),并评估糖脂谱、铁谱和心脏标志物(肌钙蛋白T和CK-MB)的水平。研究结果表明,给药马桑素恢复糖脂和铁谱,改善高血压和心脏肥厚,抑制炎症反应(p值
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Retraction Note: Morin attenuates ferroptosis via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate diabetic cardiomyopathy in vivo.

The article Morin Attenuates Ferroptosis via Activation of the SIRT1/p53/SLC7A11 Signaling Pathway to Alleviate Diabetic Cardiomyopathy In Vivo, by Qingmei Wang, Xuanguo Zhang and Li Xi, published online on March 12, 2025 has been retracted by the Editor-in-Chief and the Publisher. Following an internal investigation by the Publisher, irregularities with respect to the submission and peer review were found. Consequently, the Editor-in-Chief therefore no longer has confidence in the results and conclusions presented in the article. The authors do not agree with this retraction.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Lipid Therapy in Patients with Diabetes Mellitus. Diabetic Foot Syndrome. Muscle Function Improves After Parathyroidectomy: Role of Calcium Reduction Over PTH Decline. Hemoglobin A1c and Neuropathic Pain in Type 2 Diabetes: A Case-Control Study with the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs Questionnaire. Diabetic Ulnar Compression Neuropathy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1