Basma M. Essa, Islam M. Abdelmonem, Mohamed A. Amin, Adli A. Selim
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Silybin loaded Ag-nanoparticles as a drug delivery system for solid tumor theragnosis: Extraction, radioiodination, and biodistribution study
Biocompatible silver nanoparticles (AgNPs) are employed with an active ingredient of milk thistle extract, silybin (SIB), to treat cancers. Strong cytotoxic effects of SIB-AgNPs against two distinct cell lines (MCF-7 and HepG2) are observed on a stable nano-platform that contains spherical nanoparticles within a limited size range. With a high radiochemical purity, radioiodination of SIB-AgNPs was accomplished. The investigation on the biodistribution of [131I]iodo-SIB-AgNPs in mice-bearing tumors showed that SIB-AgNPs prefer localization in tumor tissue. In conclusion, this work strengthens the case for [131I]iodo-SIB-AgNPs as an effective theranostic agent for tumor imaging and treatment.
期刊介绍：
Archiv der Pharmazie - Chemistry in Life Sciences is an international journal devoted to research and development in all fields of pharmaceutical and medicinal chemistry. Emphasis is put on papers combining synthetic organic chemistry, structural biology, molecular modelling, bioorganic chemistry, natural products chemistry, biochemistry or analytical methods with pharmaceutical or medicinal aspects such as biological activity. The focus of this journal is put on original research papers, but other scientifically valuable contributions (e.g. reviews, minireviews, highlights, symposia contributions, discussions, and essays) are also welcome.
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