Orlee Marini-Rapoport, Moumita Bhowmik, Sarita U Patil
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引用次数: 0
摘要
综述的目的：嗜碱性粒细胞活化检测（BAT）作为过敏效应细胞活化的体外检测方法，可对体内 IgE 介导的过敏反应进行量化。因此，嗜碱性粒细胞活化测试有望用于花生和树坚果过敏的诊断和监测。最近的系统分析和专家建议都支持 BAT 在诊断花生和树坚果过敏中发挥作用：最近的研究结果：已经确定了花生和树坚果过敏 BAT 的诊断临界值。始终如一的是，在对口服食物挑战进行测量时，BAT 能以较高的灵敏度和特异性区分过敏和耐受。此外，无论是单独使用还是与特异性 IgE 检测和皮肤点刺检测结合使用，BAT 都能提高花生过敏和树坚果过敏诊断的灵敏度和特异性。在诊断花生和树坚果过敏方面，BAT 是一种很有前途的工具。
Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy.
Purpose of review: As an ex-vivo test of allergic effector cell activation, basophil activation testing (BAT) to allergen enables quantification of the in-vivo IgE-mediated allergic response. BAT thus holds promise in the diagnosis and monitoring of peanut and tree nut allergies. Recent systematic analyses and expert recommendations support a role for BAT in the diagnosis of peanut and tree nut allergy.
Recent findings: Diagnostic cut-offs for BAT in peanut and tree nut allergy have been identified. Consistently, BAT can discriminate with high sensitivity and specificity between allergy and tolerance when measured against oral food challenges. Furthermore, the utilization of BAT has can increase the sensitivity and specificity of peanut allergy and tree nut allergy diagnosis, both alone and in conjunction with specific IgE testing and skin prick testing. BAT is a promising tool in the diagnosis of peanut and tree nut allergy.
期刊介绍：
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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