海洋蓝藻产NO抑制剂Hedopeptolide

IF 3.6 2区生物学 Q2 CHEMISTRY, MEDICINAL Journal of Natural Products Pub Date : 2025-04-25 Epub Date: 2025-03-27 DOI:10.1021/acs.jnatprod.5c00095

Shunya Tojo, Noriyuki Natsume, Taiki Niino, Arihiro Iwasaki, Kiyotake Suenaga, Osamu Ohno, Toshiaki Teruya

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引用次数: 0

摘要

从日本冲绳海域的海洋蓝藻Okeania sp.中分离出一种新的19元环沉积肽hedopeptolide(1)。通过光谱分析确定了其总体结构，结晶后通过单晶x射线衍射分析确定了其手性中心的绝对构型。Hedopeptolide(1)抑制脂多糖诱导的RAW264.7细胞一氧化氮的产生。

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Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp.

A novel 19-membered cyclic depsipeptide, hedopeptolide (1), was isolated from Okeania sp., a marine cyanobacterium collected in Okinawa, Japan. Its gross structure was determined by spectroscopic analyses, and the absolute configuration of the chiral centers was determined by single-crystal X-ray diffraction analysis following crystallization. Hedopeptolide (1) inhibited the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.