异染色质在慢性粒细胞白血病中9q;22q优先易位中的作用。

R S Verma, J Rodriguez, A Babu, S Chemitiganti, M Coleman, R T Silver, H Dosik
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引用次数: 4

摘要

对55例慢性髓性白血病(CML)患者9号染色体次级收缩区(h)的大小和位置进行了评价。每个病例都通过c -带和a -4,6-二氨基-2-苯基吲哚技术检测h区域的表达。当9号染色体的一个h区较大时,它与22号染色体的反向易位发生的频率更高。此外,与正常同系物相比,易位的9号染色体的h区有更高的中心倒位发生率。9号染色体的组成性异染色质可能是CML中9q;22q易位的影响因素。
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Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia.

The secondary constriction region (h) of human chromosome 9 was evaluated in 55 chronic myelogenous leukemia (CML) patients with respect to its size and position. Each case was examined by C-banding and distamycin A-4,6-diamidino-2-phenylindole techniques for the expression of the h regions. When one h region of chromosome 9 was larger, it was more frequently involved in the reciprocal translocation with chromosome 22. In addition, there was a higher incidence of pericentric inversions in the h regions in the translocated chromosome 9 when compared with normal homologues. The role of the constitutive heterochromatin of chromosome 9 as a possible influencing factor during 9q;22q translocation in CML is suggested.

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Chromosome segregation from cell hybrids. II. Do differences in parental cell growth rates and phase times determine direction of loss? Use of Neurospora spore killer strains to obtain centromere linkage data without dissecting asci. Ascus development in two temperature-sensitive four-spore mutants of Neurospora crassa. Murine plasmacytomas constitute a class of natural heat-shock variants in which the major inducible hsp-68 gene is not expressed. Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia.
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