[脊髓多巴胺能系统]

Journal de pharmacologie Pub Date : 1986-10-01
P Mouchet, P Petitjean, B Guérin, M Manier, G Pellissier, C Feuerstein, P Demenge
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引用次数: 0

摘要

最近发现了一种新的多巴胺能神经支配:多巴胺能脊髓系统。在这篇综述中,介绍了导致这种多巴胺能系统个体化的不同步骤,以及有关其可能的解剖组织的实际可用报告结果。最后,对大部分数据进行了讨论,说明了系统可能实现的功能。有趣的是,它参与了伤害性信号的传递和心血管模式的控制,现在似乎已经得到了很好的证实。这种功能意义为中枢多巴胺能激动剂和拮抗剂的可能靶点提供了新的信息,特别是在心血管水平。
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[The spinal dopaminergic system].

A new dopaminergic innervation has been described quite recently: the dopaminergic spinal cord system. In this review are presented the different steps which lead to the individualization of this dopaminergic system and the reported results actually available concerning its probable anatomical organization. Finally, most of the data which illustrate the possible functions of this system are discussed. Interestingly, its participation in the transmission of nociceptive signals and the control of cardiovascular patterns appear now well established. Such functional implications give new information on the possible targets of central dopaminergic agonists and antagonists, particularly at the cardiovascular level.

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