巴西利什曼原虫感染的仓鼠血清蛋白抑制正常仓鼠淋巴细胞的淋巴细胞反应。

J A O'Daly, Z Cabrera
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引用次数: 0

摘要

巴西利什曼原虫(Leishmania brasiliensis, LB)或多诺瓦利什曼原虫(l.d donovani, LD)感染鼠的免疫抑制与LB感染后21、60、68和76天出现的两条血清蛋白带以及可能来自宿主的LD感染后21天出现的8条血清蛋白带相关。通过电聚焦从lb感染的仓鼠血清中分离出一条蛋白带,抑制正常淋巴细胞对T细胞和B细胞有丝分裂原的成母反应。
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Serum protein from Leishmania brasiliensis infected hamster that suppress lymphocyte response of normal hamster lymphocytes.

Immunosuppression in Leishmania brasiliensis (LB) or L. donovani (LD) infected hamsters is correlated with the appearance of two serum protein bands found at 21, 60, 68 and 76 days post LB-infection and with eight bands at 21 days post-LD-infection probably of host origin. A protein band from LB-infected hamster serum isolated by electrofocusing, suppressed the blastogenic response of normal lymphocytes to T and B cell mitogens.

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