口腔和面部麻风病变的超微结构

Peter A. Reichart , Date Metah, Jürgen Althoff
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引用次数: 2

摘要

对10例面部及腭黏膜麻风病灶不同治疗时间和长度后的超微结构进行了研究。从表现为麻风结节性红斑(ENL)的患者身上进行的活检显示出与“烧坏”和非药物病例不同的超微结构特征。在非enl病例中很少见多个继发性溶酶体。在ENL反应病例中,麻风分枝杆菌的存在和溶酶体活性的增加被解释为麻风分枝杆菌细胞质基质裂解的反应;然而,药物特异性(二氨基二苯砜)反应也必须考虑。
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Ultrastructural aspects of oral and facial lepromatous lesions

The ultrastructure of 10 lepromatous lesions in the face and the palatal mucosa after different duration and length of treatment was studied. Biopsies taken from patients who showed erythema nodosum leprosum (ENL) revealed different ultrastructural characteristics from those taken from ‘burnt out’ and non-medicated cases. Multiple secondary lysosomes were rarely seen in non-ENL cases. The presence of Mycobacterium leprae and an increased lysosomal activity in ENL reactive cases is interpreted as a reaction to the lysis of the cytoplasmic matrix of M. leprae; however, drug-specific (diaminodiphenylsulphone) reactions must also be considered.

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