局部/全身联合使用抗纤溶药物治疗接受拔牙的血友病患者

Zoran Stajčić
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引用次数: 26

摘要

43例血友病患者共拔恒牙185颗。患者资料在抗纤溶治疗方面分为3组。第一组患者给予全身抗纤溶药物治疗。第2组局部应用抗纤溶药物,第3组局部和全身应用抗纤溶药物。使用每位患者每公斤给予fviii的单位数和凝血指数(Col)来评估治疗结果。研究表明,局部使用抗纤溶药物可以减少控制出血所需的fviii量,但由于Col值高,治疗效果不理想。1组和3组均需要在干预前单次输注每位患者约20 U/kg的fviii。然而,在Col方面,在3组和1组之间发现了统计学上显著的差异。在此基础上,我们得出结论,局部和全身使用抗纤溶药物,似乎在治疗接受拔牙和接受fviii治疗的血友病患者中显示出明显的优势。
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The combined local/systemic use of antifibrinolytics in hemophiliacs undergoing dental extractions

A total of 185 permanent teeth were extracted in 43 hemophiliacs. The patient material is divided into 3 groups with respect to antifibrinolytic therapy. Patients in group 1 were given antifibrinolytics systemically. In group 2, antifibrinolytics were applied locally, and in group 3 they were used both locally and systemically. The results of the treatment were evaluated using the number of units per kilogram of F VIII administered per patient and the Coagulum Index (Col). It is shown that local use of antifibrinolytics can reduce the amount of F VIII required for the control of bleeding, but regarding the high values of the Col, the therapeutic effects are unsatisfactory. Approximately 20 U/kg of F VIII per patient, given in single infusion prior to intervention, were required in group 1 as well as in group 3. However, with respect to the Col, a statistically significant difference is found between groups 3 and 1. On this basis, it is concluded that antifibrinolytics, used both locally and systemically, appear to show distinct advantages in the treatment of hemophiliacs undergoing dental extractions and also receiving F VIII therapy.

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