Intracellular substance with some amyloid staining affinities in pancreatic acinar cells of a cat with amyloidosis.

Pancreatic amyloidosis and basophilic myelogenous sarcoma were diagnosed in a 16-year-old, spayed female domestic shorthaired cat. This report focuses attention on unusual cytoplasmic changes in pancreatic acinar cells, possibly related to extracellular amyloid, The intracellular substance in acinar cells reacted similarly to extracellular amyloid when stained with crystal violet, thioflavine T, and PAS but did not stain or elicit green birefringence with Congo red. The intracytoplasmic material in acinar cells may represent a non-fibrillar amyloid precursor. Amyloid was demonstrable only in the pancreas.