{"title":"[2-脱氧-2,3-脱氢-n -乙酰神经氨酸对黏液病毒-神经氨酸酶及流感和新城疫病毒复制的影响]。","authors":"P Meindl, G Bodo, J Lindner, P Palese","doi":"10.1515/znb-1971-0812","DOIUrl":null,"url":null,"abstract":"Neuraminidase of Influenza-A-Melbourne virus was competitively inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The inhibition constant (KI) was found to be 5.3 × 10-6 mol/l. The inhibition of different viral neuraminidases was found to vary considerably. The release of Influenza-A-Melbourne virus adsorbed to chick erythrocytes was strongly inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This substance also influenced the replication of neuraminidase containing viruses. The extent of this inhibition was variable. In contrast, the replication of viruses not containing neuraminidase was not affected.","PeriodicalId":23706,"journal":{"name":"Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete","volume":"26 8","pages":"792-7"},"PeriodicalIF":0.0000,"publicationDate":"1971-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":"{\"title\":\"[Influence of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid on Myxovirus-neuraminidases and the replication of influenza- and Newcastle disease virus].\",\"authors\":\"P Meindl, G Bodo, J Lindner, P Palese\",\"doi\":\"10.1515/znb-1971-0812\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neuraminidase of Influenza-A-Melbourne virus was competitively inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The inhibition constant (KI) was found to be 5.3 × 10-6 mol/l. The inhibition of different viral neuraminidases was found to vary considerably. The release of Influenza-A-Melbourne virus adsorbed to chick erythrocytes was strongly inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This substance also influenced the replication of neuraminidase containing viruses. The extent of this inhibition was variable. In contrast, the replication of viruses not containing neuraminidase was not affected.\",\"PeriodicalId\":23706,\"journal\":{\"name\":\"Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete\",\"volume\":\"26 8\",\"pages\":\"792-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1971-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/znb-1971-0812\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/znb-1971-0812","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Influence of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid on Myxovirus-neuraminidases and the replication of influenza- and Newcastle disease virus].
Neuraminidase of Influenza-A-Melbourne virus was competitively inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The inhibition constant (KI) was found to be 5.3 × 10-6 mol/l. The inhibition of different viral neuraminidases was found to vary considerably. The release of Influenza-A-Melbourne virus adsorbed to chick erythrocytes was strongly inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This substance also influenced the replication of neuraminidase containing viruses. The extent of this inhibition was variable. In contrast, the replication of viruses not containing neuraminidase was not affected.
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