Placental transfer of phosphomycin.

The transfer of phosphomycin across the placental barrier was studied after a single injection of the sodium salt of phosphomycin to the mother during active labour. The concentrations of the antibiotic in maternal and fetal blood were determined and a high and rapid transfer of the antibiotic, reaching 50% of the maternal blood level after 1.5 h, was observed, which theoretically could be effective in the fetus against a large number of the germs which can be responsible for intrauterine infections.