{"title":"中隔和下丘脑病变大鼠高反应性的药理改变","authors":"C.W. Beattie , H.I. Chernov , P.S. Bernard , F.H. Glenny","doi":"10.1016/0028-3908(69)90023-9","DOIUrl":null,"url":null,"abstract":"<div><p>Lesions were electrolytically placed in the septal area and/or hypothalamus of male albino rats using a stereotaxic instrument and well-defined co-ordinates. The effect of various types of pharmacological agents on the induced hyper-reactivity has been determined. All classes of compounds tested reduced to varying degrees the hyper-reactivity produced by septal lesions. Chlorpromazine and morphine also reduced the hyper-reactivity of rats with hypothalamic and hypothalamic-septal lesions, though only to a limited extent. Possible mechanisms and sites of action are discussed.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90023-9","citationCount":"13","resultStr":"{\"title\":\"Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions\",\"authors\":\"C.W. Beattie , H.I. Chernov , P.S. Bernard , F.H. Glenny\",\"doi\":\"10.1016/0028-3908(69)90023-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lesions were electrolytically placed in the septal area and/or hypothalamus of male albino rats using a stereotaxic instrument and well-defined co-ordinates. The effect of various types of pharmacological agents on the induced hyper-reactivity has been determined. All classes of compounds tested reduced to varying degrees the hyper-reactivity produced by septal lesions. Chlorpromazine and morphine also reduced the hyper-reactivity of rats with hypothalamic and hypothalamic-septal lesions, though only to a limited extent. Possible mechanisms and sites of action are discussed.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1969-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(69)90023-9\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390869900239\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900239","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pharmacological alteration of hyper-reactivity in rats with septal and hypothalamic lesions
Lesions were electrolytically placed in the septal area and/or hypothalamus of male albino rats using a stereotaxic instrument and well-defined co-ordinates. The effect of various types of pharmacological agents on the induced hyper-reactivity has been determined. All classes of compounds tested reduced to varying degrees the hyper-reactivity produced by septal lesions. Chlorpromazine and morphine also reduced the hyper-reactivity of rats with hypothalamic and hypothalamic-septal lesions, though only to a limited extent. Possible mechanisms and sites of action are discussed.